Fwd: [MEDFAM-APS] Metaanálisis de los efectos cardiovasculares de los inhibidores SGLT-2

Desde blog redgedaps

Metaanálisis de los efectos cardiovasculares de los inhibidores SGLT-2

http://redgedaps.blogspot.com.es/2016/03/metaanalisis-de-los-efectos.html

Sorprenden sus efectos en la mortalidad cuando apenas afecta al IAM y la angina inestable y son contraproducentes con los AVC

Efecto de clase, al parecer

Wu JH, Foote C, Blomster J, Toyama T, Perkovic V, Sundström J, Neal B. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2016 Mar 18. pii: S2213-8587(16)00052-8. doi: 10.1016/S2213-8587(16)00052-8. [Epub ahead of print]

Zinman B1, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, Broedl UC, Inzucchi SE; EMPA-REG OUTCOME Investigators. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015 Sep 17. [Epub ahead of print]

Vasilakou D, et al Sodium–Glucose Cotransporter 2 Inhibitors for Type 2 Diabetes A Systematic Review and Meta-analysis. Ann Intern Med. 2013;159(4):262-274. doi:10.7326/0003-4819-159-4-201308200-00007

Berhan A1, Barker A. Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials. BMC Endocr Disord. 2013 Dec 17;13(1):58. doi: 10.1186/1472-6823-13-58.

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