Supported by a grant (AOM09002) from the French Ministry of Health, by SOS–Attaque Cérébrale Association, and by grants from Pfizer, AstraZeneca, and Merck for the French sites and from Pfizer for the South Korean sites.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
Dr. Amarenco reports receiving grant support, paid to SOS Attaque Cerebrale Association, lecture fees, consulting fees, and fees for serving on an executive committee from AstraZeneca, fees for serving on a steering committee, lecture fees, and consulting fees from Bayer, consulting fees and lecture fees from Daiichi Sankyo, grant support, paid to SOS Attaque Cerebrale Association, lecture fees, and consulting fees from Boston Scientific, fees for serving on an end-point committee from GlaxoSmithKline, consulting fees and fees for serving on an executive committee from Kowa, fees for serving on a data and safety monitoring board from Fibrogen and Shin Poong, grant support, paid to SOS Attaque Cerebrale Association, lecture fees, and advisory board fees from Sanofi, grant support, paid to SOS Attaque Cerebrale Association, lecture fees, and fees for serving on a steering committee from Bristol-Myers Squibb, fees for serving on a steering committee from Portola, and consulting fees from Gilead; Dr. J.S. Kim, receiving grant support from Dong-A Pharmaceutical, Servier, Daiichi Sankyo, and Shin Poong; Dr. Abtan, receiving advisory board fees and lecture fees from AstraZeneca and lecture fees from Bayer and Bristol-Myers Squibb; Dr. Bejot, receiving consulting fees from AstraZeneca and Daiichi Sankyo, consulting fees and lecture fees from Bristol-Myers Squibb, Medtronic, and Boehringer Ingelheim, and lecture fees from Pfizer, Bayer, and Merck Sharp and Dohme; Dr. Cabrejo, receiving lecture fees from Biogen and Teva and advisory board fees from Roche; Dr. Cha, receiving lecture fees and travel support from Bristol-Myers Squibb/Pfizer, lecture fees and consulting fees from Medtronic, and lecture fees from Bayer, Boehringer Ingelheim, and Amgen; Dr. Ducrocq, receiving consulting fees and lecture fees from Amgen, AstraZeneca, Bayer, Bristol-Myers Squibb, and Sanofi, and consulting fees from Janssen; Dr. Giroud, receiving training and travel support from Bayer, Boehringer Ingelheim, Pfizer, AstraZeneca, Bristol-Myers Squibb, and Daiichi Sankyo; Dr. Guidoux, receiving consulting fees from Bayer and Boehringer Ingelheim; Dr. Lapergue, receiving grant support and consulting fees from Stryker, grant support from MicroVention and Penumbra, and consulting fees from Bristol-Myers Squibb and Boehringer Ingelheim; Dr. B.-C. Lee, receiving grant support from Boehringer Ingelheim, Bayer, Daiichi Sankyo, Eisai, and AstraZeneca; Dr. K.-B. Lee, receiving grant support from AstraZeneca, Daiichi Sankyo, Boryung, and Shin Poong and consulting fees and advisory board fees from Cheil; Dr. Leys, receiving grant support, paid to his institution, from Pfizer and Bayer Pharma; Dr. Nighoghossian, receiving grant support from Pfizer and Sanofi and consulting fees from Boehringer Ingelheim, Bayer, and Amgen; Dr. Pico, receiving lecture fees and travel support from Bristol-Myers Squibb/Pfizer, lecture fees and consulting fees from Medtronic, and lecture fees from Bayer, Boehringer Ingelheim, and Amgen; Dr. Steg, receiving grant support and fees for serving on a steering committee from Bayer/Janssen, grant support and lecture fees from Merck, grant support, consulting fees, lecture fees, and fees for serving as trial cochair from Sanofi, grant support, consulting fees, and fees for serving on an executive steering committee from Amarin, consulting fees and lecture fees from Amgen, consulting fees, lecture fees, and fees for serving on a critical-event committee from Bristol-Myers Squibb, fees for serving on an executive steering committee from Boehringer Ingelheim, fees for serving on a critical-event committee from Pfizer, consulting fees and fees for serving on an executive steering committee from Novartis, consulting fees and fees for serving as trial cochair from Regeneron, consulting fees from Eli Lilly, consulting fees and lecture fees from AstraZeneca, grant support, fees for serving as chair of a data monitoring committee, and fees for serving as chair of a registry for Servier, consulting fees from Novo Nordisk, and fees for serving on a steering committee from Idorsia; Dr. Sung, receiving lecture fees from Daiichi Sankyo Korea, Korea Otsuka Pharmaceutical, Shin Poong, and Bayer Korea; Dr. Touboul, holding stock in Intelligence in Medical Technologies; Dr. Varenne, receiving grant support from Boston Scientific, lecture fees from Abbott Vascular, AstraZeneca, and Servier, and travel support from Biosensors; Dr. Vicaut, receiving consulting fees from Abbott, Bristol-Myers Squibb, Celgene, LFB Technologies, and Pfizer, lecture fees from Novartis, and grant support, paid to his institution, and consulting fees from Sanofi; and Dr. Bruckert, receiving lecture fees and travel support from Merck Sharp and Dohme, lecture fees and honoraria from Akcea, Servier, Sanofi Aventis, Amgen, and Aegerion Amryt, fees for serving as president of a data and safety monitoring board from Genfit, honoraria from Regeneron, and advisory board fees from Mylan. No other potential conflict of interest relevant to this article was reported.
This article was published on November 18, 2019, at NEJM.org.
A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.
