Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMc2119270#.Yc1RnRhgz0Q.twitter

SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron | medRxiv

https://www.medrxiv.org/content/10.1101/2021.12.26.21268380v1

Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves | Global Health | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2787776?guestAccessKey=3ce0526a-20a1-4d9a-ba1b-0d26636a71da&utm_source=twitter&utm_medium=social_jama&utm_term=6139815954&utm_campaign=article_alert&linkId=146260188


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ALTA TASA DE ASINTOMATICOS CON OMICRON

https://www.medrxiv.org/content/10.1101/2021.12.20.21268130v1.full.pdf

SARS-CoV-2 Omicron VOC Transmission in Danish Households | medRxiv

https://www.medrxiv.org/content/10.1101/2021.12.27.21268278v1

US officials recommend shorter COVID isolation, quarantine | AP News

https://apnews.com/article/coronavirus-pandemic-science-business-health-rochelle-walensky-d7d609c9c01e200d250df7ca7282c9d6?utm_campaign=SocialFlow&utm_source=Twitter&utm_medium=AP

COVID-19 vaccine breakthrough infections

https://www.science.org/doi/10.1126/science.abl8487

Saliva swabs are the preferred sample for Omicron detection | medRxiv

https://www.medrxiv.org/content/10.1101/2021.12.22.21268246v1

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naïve and subjects recovered from COVID-19 - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S2211124721017447


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Vacuna hetero trombosis

https://www.nejm.org/doi/pdf/10.1056/NEJMc2118507?articleTools=true


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The role of European health system characteristics in affecting Covid 19 lethality during the early days of the pandemic | Scientific Reports

https://www.nature.com/articles/s41598-021-03120-2

2021 in Review

https://www.medscape.com/viewarticle/963483?src=soc_tw_211225_mscpedt_news_mdscp_review&faf=1

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant: Cell

 

https://www.cell.com/cell/fulltext/S0092-8674(21)01496-3#relatedArticles

Ómicron: proponer soluciones – microBIOblog

https://microbioblog.es/omicron-proponer-soluciones

Neutralization and Stability of SARS-CoV-2 Omicron Variant | bioRxiv

https://www.biorxiv.org/content/10.1101/2021.12.16.472934v1

SAGE 99 minutes: Coronavirus (COVID-19) response, 16 December 2021 - GOV.UK

https://www.gov.uk/government/publications/sage-99-minutes-coronavirus-covid-19-response-16-december-2021/sage-99-minutes-coronavirus-covid-19-response-16-december-2021

Saliva is the Key Element for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Mass Screening | Clinical Infectious Diseases | Oxford Academic

https://academic.oup.com/cid/article/73/3/e566/5933821

Saliva for molecular detection of SARS-CoV-2 in school-age children - PubMed

https://pubmed.ncbi.nlm.nih.gov/33618013/

Validation of an At-Home Direct Antigen Rapid Test for COVID-19 | Infectious Diseases | JAMA Network Open | JAMA Network

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783550

Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2106599?query=featured_home

Op-Ed: Pandemic fatigue has Americans glossing over Omicron. But we can't give up - Los Angeles Times

https://www.latimes.com/opinion/story/2021-12-16/omicron-infection-delta-complacency-hospitalization

‘No evidence’ Omicron is less severe than Delta, say UK researchers | Financial Times

https://www.ft.com/content/020534b3-5a54-4517-9fd1-167a5db50786

ECDC publishes new risk assessment on further emergence of Omicron variant

NO tiene desperdicio, dado el riesgo de la variante OMICRON ECDC convencido que solo con vacunas no vamos a llegar, publica estas recomendaciones.

https://www.ecdc.europa.eu/en/news-events/ecdc-publishes-new-risk-assessment-further-emergence-omicron-variant

Fwd: booster, Omicron, y otras bestezuelas del campo.

En este articulo el booster mejora el control de omicron y el que mas el utilizado con moderna. 

https://www.biorxiv.org/content/10.1101/2021.12.12.472269v1

Los comentarios en twitter de Tomas Pueyo causan bastante inquietud. Sobre si esta cepa altamente transmisible puede generar aunque menos letal (mortalidad relativa)un mayor  numero de casos, y mas mortalidad global.

https://unchartedterritories.tomaspueyo.com/p/the-omicron-question

Covid-19: Omicron and the need for boosters.

https://www.bmj.com/content/bmj/375/bmj.n3079.full.pdf

mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant | medRxiv

https://www.medrxiv.org/content/10.1101/2021.12.14.21267769v1

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant | medRxiv

https://www.medrxiv.org/content/10.1101/2021.12.14.21267755v1

SINDROME CORONARIO

https://www.nps.org.au/assets/AP/pdf/p180-Eng-Frost-Chew.pdf

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report | medRxiv

https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v2

Antibody titers before and after booster doses of SARS-CoV-2 mRNA vaccines in healthy adults | medRxiv

https://www.medrxiv.org/content/10.1101/2021.11.19.21266555v1

Comparative effectiveness of mRNA-1273 and BNT162b2 against symptomatic SARS-CoV-2 infection: Med

https://www.cell.com/med/fulltext/S2666-6340(21)00382-2

Avances en gestión clínica: ¿Es posible evaluar los resultados de la integraci...

Avances en gestión clínica: ¿Es posible evaluar los resultados de la integraci...: Jordi Varela Editor La integración de servicios es una estrategia imprescindible para afrontar los retos que plantean las personas con neces...

SARS-CoV-2 B.1.1.529 (Omicron) Variant — United States, December 1–8, 2021 | MMWR historia de 40 pacientes USA

sintomas y evolucion de 40 pacientes OMICRON

https://www.cdc.gov/mmwr/volumes/70/wr/mm7050e1.htm?s_cid=mm7050e1_w

historia 7 pacientes sudafrica sintomas y evolucion.Breakthrough infections with SARS-CoV-2 Omicron variant despite booster dose of mRNA vaccine by Constanze Kuhlmann, Carla Konstanze Mayer, Mathilda Claassen, Tongai G. Maponga, Andrew D. Sutherland, Tasnim Suliman, Megan Shaw, Wolfgang Preiser :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3981711

eficacia y seguridad del booster

https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-11-19/02-COVID-Perez-508.pdf

Effectiveness of a motivational intervention based on spirometry results to achieve smoking cessation in primary healthcare patients: randomised, parallel, controlled multicentre study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458052/

Tercera dosis y proteccion mortalidad

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2115624?articleTools=true

good news vacunas covid tercera dosis

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2115926?articleTools=true

RV: peligrosos datos de Omicron.

---

 

https://www.ahri.org/wp-content/uploads/2021/12/MEDRXIV-2021-267417v1-Sigal.pdf

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection Sandile Cele1,2, Laurelle Jackson1, Khadija Khan1,2 ,David Khoury3, Thandeka Moyo-Gwete4,5, Houriiyah Tegally6,7, Cathrine Scheepers4,5, Daniel Amoako4, Farina Karim1,2, Mallory Bernstein1, Gila Lustig8, Derseree Archary8, Muneerah Smith9, Yashica Ganga1, Zesuliwe ... www.ahri.org

SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports | BMC Gastroenterology | Full Text

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-021-01905-3

¿Por que me vacunan con Moderna II...?

Quizas este reciente articulo de Lancet da respuesta. Tanto si se basa de una pauta inicial doble de astra zeneca como si se trata de una pauta inicial doble de Pfizer parece que moderna es la que prodece una tasa mas alta de anticuerpos( resultado u output intermedio no de resultado final). Compara 7 tipos(vacunas diferentes o dosis) en el booster.

Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02717-3/fulltext#seccestitle160

Optimising SARS-CoV-2 vaccination schedules | Elsevier Enhanced Reader

https://reader.elsevier.com/reader/sd/pii/S0140673621017293?token=EC2CA37BA2124FD9942CBFC07289949C2200D2655050E1D93EFFFC6DB4D82601D60CF387243501DDFC85469BC8D0ECE7&originRegion=eu-west-1&originCreation=20211204130015

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0140673621016949?casa_token=yVkbsRtmQOMAAAAA:pAUo31cErIOzBg6lfLAXM5gcmZ6MhpfMhvarp1VeYDoZkLWQMn6CjQYroAh3C14qDg6Iu_KdDw

vacunacion heterologa inmunidad

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528081/pdf/nihpp-2021.10.10.21264827v2.pdf

¿Por que con moderna, si me vacune con Pfizer?

como muchos os estais preguntando en que se basan para la dosis recuerdo moderna:

Waning immunity of the BNT162b2 vaccine: A nationwide study from Israel; perdida de inmunidad con el tiempo… de las vacunas

1. 
   

Https://www.medrxiv.org/content/10.1101/2021.08.24.21262423v1

1. 
   

1. 
   

2. ECDC. Interim public health considerations for the provision of additional COVID-19 vaccine doses. Technical report, 1 September 2021. 

   Initial studies have shown that an additional COVID-19 vaccine dose in immunocompromised individuals enhances antibody response. Several studies thus far have looked at seropositive responses with a third mRNA COVID-19 vaccine dose in immunosuppressed people. Among immunocompromised individuals who had no detectable antibody response following a full COVID-19 vaccination course, 33-50% developed an antibody response to an additional third dose [83-87].

   Disponible en: 

   https://www.ecdc.europa.eu/en/publications-data/covid-19-public-health-considerations-additional-vaccine-doses

   https://www.ecdc.europa.eu/sites/default/files/documents/Interim-public-health-considerations-for-the-provision-of-additional-COVID-19-vaccine-doses.pdf

   y 

   Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

   estudio hecho con Pfizer–BioNTech

   
   

   
   
   https://www.nejm.org/doi/10.1056/NEJMoa2114255

   68. Ducloux D, Colladant M, Chabannes M, Yannaraki M, Courivaud C. Humoral response after 3 doses of the BNT162b2 mRNA COVID-19 vaccine in patients on hemodialysis. Kidney Int [Preprint]. 2021. DOI: 10.1016/j.kint.2021.06.025. Available at: https://www.sciencedirect.com/science/article/pii/S0085253821006554

       3 doses of BNT162b2 (Pfizer–BioNTech)

   69. Espi M, Charmetant X, Barba T, Pelletier C, Koppe L, Chalencon E, et al. Justification, safety, and efficacy of a third dose of mRNA vaccine in maintenance hemodialysis patients: a prospective observational study. medRxiv [Preprint]. 2021. DOI: 10.1101/2021.07.02.21259913. Available at: https://www.medrxiv.org/content/10.1101/2021.07.02.21259913v1

       BNT162b2, and the safety and impact on immune responses of a 3rd dose (3D).

   70. Kamar N, Abravanel F, Marion O, Couat C, Izopet J, Del Bello A. Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients. N Engl J Med. 2021;385(7):661-2. Available at: https://www.nejm.org/doi/10.1056/NEJMc2108861

       three doses of the messenger RNA vaccine BNT162b2 (Pfizer–BioNTech).

   71. Longlune N, Nogier MB, Miedouge M, Gabilan C, Cartou C, Seigneuric B, et al. High immunogenicity of a messenger RNA based vaccine against SARS-CoV-2 in chronic dialysis patients. Nephrol Dial Transplant [Preprint]. 2021. DOI: 10.1093/ndt/gfab193. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34057463

       three doses of the messenger RNA vaccine BNT162b2 (Pfizer–BioNTech).

   72. Werbel WA, Boyarsky BJ, Ou MT, Massie AB, Tobian AAR, Garonzik-Wang JM, et al. Safety and Immunogenicity of a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series. Ann Intern Med. 2021 Available at: https://www.acpjournals.org/doi/full/10.7326/L21-0282 

       combinacion de vacunas RNA-jansen-etc.

    

   Recomendaciones de administración de dosis de recuerdo frente a COVID-19

   https://www.mscbs.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/covid19/docs/Dosis_de_recuerdo_frente_a_COVID_trasCSP_23nov2021.pdf

   
   

   Aprobado por la Comisión de Salud Pública, el 23 de noviembre de 2021 

   
   

   En ellas recomienda dosis recuerdo vacunas de ARNm (0,3 ml de Comirnaty o 0,25 ml de Spikevax independientemente de la vacuna utilizada en la primovacunación.

    no he encontrado ningun paper que avale o refute esta decisión. Esta reciente publicacion mezcla diferentes vacunas con buenos resultados de inmunogenicidad t efectos secundarios.
   

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02717-3/fulltext

3. Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dose after two doses of ChAdOx1 nCov-19 (Oxford–AstraZeneca; hereafter referred to as ChAd) or BNT162b2 (Pfizer–BioNtech, hearafter referred to as BNT).
4. 
   

5. 
   

Opinión sanitaria : Cuál es la posibilidad de reinfección por la COVID...

Opinión sanitaria : Cuál es la posibilidad de reinfección por la COVID...:   Cuál es la posibilidad de reinfección por la COVID-19 y cuál es su evolución clínica Hace algunos días hablamos en el blog hermano “Qui pr...

covid preparacion pandemia BMJ

Editorial

Ending this pandemic and securing the future
Act quickly and collectively to transform global systems for preparedness and response

Analysis

Resetting international systems for pandemic preparedness and response
Sudhvir Singh and colleagues summarise the recommendations of the Independent Panel for Pandemic Preparedness and Response to try to prevent future pandemics

From response to transformation: how countries can strengthen national pandemic preparedness and response systems
Victoria Haldane and colleagues delve into the characteristics of national responses to covid-19. They suggest actionable steps at a national level that can guide states to achieve the independent panel's recommendations for making this the last pandemic

Aggressive containment, suppression, and mitigation of covid-19: lessons learnt from eight countries
Shishi Wu and colleagues examine three distinct response strategies for covid-19 in eight countries and argue that aggressive containment is the optimal approach to limiting loss of lives and livelihoods and achievable in the absence of vaccines and effective therapies

Strengthening the basics: public health responses to prevent the next pandemic
Victoria Haldane and colleagues argue that to make covid-19 the last pandemic, public health responses to outbreaks must be strengthened, starting with their most basic functions

Vaccines, therapeutics, and diagnostics for covid-19: redesigning systems to improve pandemic response
Rohit Ramchandani and colleagues propose a framework to ensure essential public health tools are fairly distributed in future pandemics

Investing in trust and community resilience: lessons from the early months of the first digital pandemic
Salma M Abdalla and colleagues examine how an atmosphere of misinformation, disinformation, and erosion of trust shaped the early response to covid-19 on both global and national levels

Assessing the role of qualitative factors in pandemic responses
Melisa Tan and colleagues argue that assessments of national pandemic preparedness and response capacities should be extended to include social factors, leadership, and use of evidence

From dichotomisation towards intersectionality in addressing covid-19
Anne-Sophie Jung and colleagues argue that understanding mechanisms of response to the covid-19 pandemic as trade-offs reinforces false dichotomies and hamstrings attempts to create stronger and more equitable health systems

National responses to covid-19: drivers, complexities, and uncertainties in the first year of the pandemic
Anne-Sophie Jung and colleagues argue that research and policy making must embrace complexity to build sustainable and long term approaches to pandemic preparedness

NUEVAS GUIAS EPOC

Guia Gold 2022

https://goldcopd.org/2022-gold-reports/

GESEPOC 2021

https://www.archbronconeumol.org/es-actualizacion-2021-guia-espanola-epoc-avance-S0300289621001034

Heavily mutated coronavirus variant puts scientists on alert

https://www.nature.com/articles/d41586-021-03552-w


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Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections

https://www.nejm.org/doi/full/10.1056/NEJMc2108120

Organización de la Atención Primaria en tiempos de pandemia - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0212656721002432

vacunación y hospitalización. COVID-19

Summary

• For all adults aged 18 years and older, the cumulative COVID-19-associated hospitalization rate was about 12 times higher in unvaccinated persons.
• Although weekly rates can vary, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 18-49 years was about 14 times higher than fully vaccinated adults aged 18-49 years.
• Although weekly rates can vary widely, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 50-64 years was about 15 times higher than fully vaccinated adults aged 50-64 years.
• Although weekly rates can vary widely, the cumulative rate of COVID-19-associated hospitalizations in unvaccinated adults ages 65 years and older was about 9 times higher than fully vaccinated adults ages 65 years and older.

or more information about COVID-NET, please see 
https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covid-net/purpose-methods.html .

Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis

https://www.bmj.com/content/375/bmj-2021-068302

DATOS EN SALUD

https://www.enriquedans.com/2021/11/la-necesariamente-cambiante-consideracion-de-los-datos-de-salud.html

CDC COVID Data Tracker

https://covid.cdc.gov/covid-data-tracker/#rates-by-vaccine-status

Direct Comparison of Antibody Responses to Four SARS-CoV-2 Vaccines in Mongolia: Cell Host & Microbe

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00510-2

When and how to deintensify type 2 diabetes care | The BMJ

https://www.bmj.com/content/375/bmj-2021-066061.short?rss=1&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+bmj/recent+(Latest+from+BMJ)

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb: Cell

https://www.cell.com/cell/fulltext/S0092-8674(21)01282-4


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Carga anticolinérgica: recomendaciones

https://www.cadime.es/bta/bta/869-carga-anticolinérgica-recomendaciones.html


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Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

Diferencias entre dos y tres dosis frente a ingresos

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02249-2/fulltext

Guía actuación dermatología

https://www.riojasalud.es/files/content/newsletter/20210322/20210322_n1.pdf


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Screening for SARS-CoV-2 by RT-PCR: Saliva or nasopharyngeal swab? Rapid review and meta-analysis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191978/

Focusing on Digital Health Equity | Health Disparities | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2785583?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=102321#.YXPReJCf9T4.twitter


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PARADOJA DE LA ATENCION PRIMARIA

Para mi siempre un referente Ernesto Barrera

@ernestob lo comparte en su twitter.

Reglas simples que guían la atención generalista y especializada [Fam Med] Gran artículo que merece estar en la lista de los mejores, como lectura obligada para entender la "paradoja de la Atención Primaria" y su valor en los sistemas sanitarios

https://journals.stfm.org/familymedicine/2021/september/stange-2020-0588

The Immune System Is an Early Riser, Research Shows

The migration of dendritic cells to the lymphatic system oscillates according to the time of day, suggesting certain times are associated with higher immune system activity.  https://www.medscape.com/viewarticle/961151?src=soc_tw_211021_mscpedt_news_mdscp_immune&faf=1

Opinión sanitaria : El especialista tutorizado

Opinión sanitaria : El especialista tutorizado: El especialista tutorizado Los que somos tutores de la especialidad de Medicina Familiar y Comunitaria (MFyC) desde hace muchos años, sabemo...

Fatal breakthrough infection after anti-BCMA CAR-T therapy highlights suboptimal immune response to SARS-CoV-2 vaccination in myeloma patients

https://www.medrxiv.org/content/10.1101/2021.05.15.21256814v1

Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis | The BMJ

https://www.bmj.com/content/375/bmj.n2321?utm_source=twitter&utm_medium=social&utm_term=hootsuite&utm_content=sme&utm_campaign=usage

La biblioteca de Springfield: Seguridad de las vacunas en esta epidemia

La biblioteca de Springfield: Seguridad de las vacunas en esta epidemia: La seguridad de las vacunas pandémicas ha sido cuestionada desde antes de que se publicaran los ensayos clínicos de seguridad y eficacia y s...

La continuidad asistencial es salud.(BIBLIOTECA DE SPRINGFIELD)

En septiembre el British Journal of General Practice publicó un estudio noruego, que tenia como objetivo analizar la atención longitudinal con médicos de atención primaria asignados, frente a resultados como internación y mortalidad. Se incluyeron 4,5 millones de residentes de Noruega, es decir a un 85% de la población de ese pais y se encontró que la mayor duración de la relación entre el médico de atención primaria y sus pacientes se asocia con menos hospitalizaciones agudas y menor mortalidad, hasta el punto de que si la continuidad longitudinal se mantiene durante más de 15 años, la probabilidad de acudir a urgencias, ingresar y morir cae entre un 25% y un 30%. Aunque se puede observar una disminución del 13% ya en el primer año.

https://bjgp.org/content/early/2021/10/04/BJGP.2021.0340

A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain | Atención Primaria

https://www.elsevier.es/es-revista-atencion-primaria-27-avance-resumen-a-systematic-review-meta-analysis-effectiveness-S0212656721001785


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Myocarditis and Pericarditis After Vaccination for COVID-19

https://jamanetwork.com/journals/jama/fullarticle/2782900?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=100421#.YVttesM5X0A.twitter

Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada | CMAJ

https://www.cmaj.ca/content/early/2021/10/04/cmaj.211248


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Gatekeeper: IA y big data al servicio de las personas mayores

https://www.redaccionmedica.com/secciones/tecnologia/gatekeeper-inteligencia-artificial-y-big-data-al-servicio-de-los-mayores-9231


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Journal of Medical Internet Research - Characteristics of Citizens and Their Use of Teleconsultations in Primary Care in the Catalan Public Health System Before and During the COVID-19 Pandemic: Retrospective Descriptive Cross-sectional Study

https://www.jmir.org/2021/5/e28629


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Covid metabolismo

https://www.thelancet.com/action/showPdf?pii=S2213-8587%2821%2900244-8


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Ct Values Do Not Predict Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmissibility in College Students Di Tian Zhen Lin Ellie M. Kriner Lee Hamm Patrice Delafontaine Xiao-Ming Yin Show all authors

https://www.jmdjournal.org/article/S1525-1578(21)00163-X/fulltext#.YVoAXUVnAVA.twitter

Lecciones aprendidas durante la pandemia COVID-19 sobre el seguimiento de pacientes crónicos | Atención Primaria

https://www.elsevier.es/es-revista-atencion-primaria-27-articulo-lecciones-aprendidas-durante-pandemia-covid-19-S0212656721002146


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Quid pro quo: ¿La reinfección por el virus SARS-CoV-2 es posible?

Quid pro quo: ¿La reinfección por el virus SARS-CoV-2 es posible?: ¿La reinfección por el virus SARS-CoV-2 es posible? Con la crisis de las nuevas variedades del virus SARS-CoV-2   se está estableciendo unos...

No Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Groups Infected with SARS-CoV-2 Delta Variant | medRxiv

https://www.medrxiv.org/content/10.1101/2021.09.28.21264262v1

Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States

CDC now recommends that people aged 65 years and older, residents in long-term care settings, and people aged 50–64 years with underlying medical conditions should receive a booster shot of Pfizer-BioNTech’s COVID-19 Vaccine at least 6 months after completing their Pfizer-BioNTech primary series. Other groups may receive a booster shot based on their individual risk and benefit. 

 https://www.cdc.gov/vaccines/covid-19/clinical-considerations/covid-19-vaccines-us.html?CDC_AA_refVal=https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html#pregnant

Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19 - PubMed

https://pubmed.ncbi.nlm.nih.gov/34183003/

Quantifying impacts of the COVID-19 pandemic through life-expectancy losses: a population-level study of 29 countries | International Journal of Epidemiology | Oxford Academic

https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyab207/6375510

Covid-19: England sees biggest fall in life expectancy since records began in wake of pandemic | The BMJ

https://www.bmj.com/content/374/bmj.n2291?utm_source=twitter&utm_medium=social&utm_term=hootsuite&utm_content=sme&utm_campaign=usage

When taking a step back is a veritable leap forward. Reversing decades of arthroscopy for managing joint pain: five reasons that could explain declining rates of common arthroscopic surgeries | British Journal of Sports Medicine

https://bjsm.bmj.com/content/54/22/1312

Diffusion of Innovations in Service Organizations: Systematic Review and Recommendations

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690184/

Opinión sanitaria : Los recursos y la prevención primaria/secundaria d...

Desde medfam he leido esta magnifica discusión sobre sangra oculta en heces si/no derivacion digestivo:

la opinion en blog Borinot.

Opinión sanitaria : Los recursos y la prevención primaria/secundaria d...:  Los recursos y la prevención primaria/secundaria del cáncer de colon Un problema que se nos ha presentado recientemente a los médicos Atenc...

Una respuesta de jose Maria Tallon en MEDfam :

Lamento volver a hacer de abogado del diablo, pero cito FMC, Protocolo de patología prostática, 2017:

"El Programa de actividades preventivas y de promoción de la salud de la Sociedad Española de Medicina de Familia y Comunitaria no recomienda el PSA de cribado en personas asintomáticas.
Las recientes recomendaciones del U.S. Preventive Task Force están en sintonía con estas recomendaciones".

En cuanto al cribado de cáncer de colon, es bien sabido que la reducción de mortalidad por dicha patología puede llegar al 22% en las mejores series siempre que se haga la TSOH cada 2 años. Pero la reducción de mortalidad total, al menos en toda la bibliografía que he consultado, que no es poca, es de 0 patatero. O sea, en mi modesta y discutible opinión, es un marrón (nunca mejor dicho) que te hace perder tiempo y te da sustos, pero para nada te alarga la vida.

Por lo tanto no me parece ningún pecado no hacer estos cribados en la consulta de Atención Primaria. 

Creo que los dos autores tienen su razón y que es bueno conocerlas para tomar nuestra decisión personal.

Assisted dying: a question of when, not if | The BMJ

https://www.bmj.com/content/374/bmj.n2128

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2 - ScienceDirect

Despite remarkable progress in the development and authorization of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to validate vaccine platforms for broader application. The current intramuscular vaccines are designed to elicit systemic immunity without conferring mucosal immunity in the nasal compartment, which is the first barrier that SARS-CoV-2 virus breaches before dissemination to the lung. We report the development of an intranasal subunit vaccine that uses lyophilized spike protein and liposomal STING agonist as an adjuvant. This vaccine induces systemic neutralizing antibodies, IgA in the lung and nasal compartments, and T-cell responses in the lung of mice. Single-cell RNA sequencing confirmed the coordinated activation of T/B-cell responses in a germinal center-like manner within the nasal-associated lymphoid tissues, confirming its role as an inductive site to enable durable immunity. The ability to elicit immunity in the respiratory tract can prevent the establishment of infection in individuals and prevent disease transmission.

 

https://www.sciencedirect.com/science/article/pii/S2589004221010051

COVID-19 vaccines: Keeping pace with SARS-CoV-2 variants: Cell

https://www.cell.com/cell/fulltext/S0092-8674(21)01057-6


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Covid vacuna inmunodepresion cd20 artritis

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(21)00251-4/fulltext?s=03 

Tipos visita atencion primaria covid

https://www.jmir.org/2021/9/e29622?s=03 

Caos y gestión

https://www.dendramedica.es/revista/v5n2/Reinterpretando_la_gestion_del_sistema_sanitario_desde_las_teorias_de_la_complejidad_y_el_caos.pdf


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La utilidad de los correos masivos | Saludconcosas

https://saludconcosas.es/la-utilidad-de-los-correos-masivos/


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La gestión sanitaria orientada hacia la calidad y seguridad de los pacientes 2ª Edic

https://documentacion.fundacionmapfre.org/documentacion/publico/i18n/catalogo_imagenes/grupo.cmd?path=1101694


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An update on non-thyroidal illness syndrome | SpringerLink

https://link.springer.com/article/10.1007/s40618-020-01482-4


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Association Between Physician Part-time Clinical Work and Patient Outcomes | Health Care Quality | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2784166


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Considerations in boosting COVID-19 vaccine immune responses

 paper de Lancet

Salud, dinero y atención primaria: ¿Evitó la vacuna tanta muerte por covid19 en ancia...

Salud, dinero y atención primaria: ¿Evitó la vacuna tanta muerte por covid19 en ancia...:   Sostiene el Ministerio de Sanidad que “las vacunas evitaron 3.500 muertes en residencias solo en el primer trimestre de 2021” ( aquí ). Se...

Medico‐legal risks associated with fragmented GP care | InSight+

https://insightplus.mja.com.au/2021/31/medico‐legal-risks-associated-with-fragmented-gp-care/

Early Warning Signs of Burnout and Functional Impairment in Healthcare Workers During the COVID-19 Pandemic

https://www.jwatch.org/na54028/2021/09/09/early-warning-signs-burnout-and-functional-impairment


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Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors - Fraile Navarro - - International Journal of Clinical Practice - Wiley Online Library

https://onlinelibrary.wiley.com/doi/10.1111/ijcp.14805#.YTuq4hoMMhE.twitter


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Predictors of Nonseroconversion after SARS-CoV-2 Infection

 enlace a articulo

Resultados vacunacion moderna

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3916094&s=03 

Interaction Time with Electronic Health Records: A Systematic Review

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0041-1733909

Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution | medRxiv

https://www.medrxiv.org/content/10.1101/2021.08.30.21262701v1


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Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021 | MMWR

https://www.cdc.gov/mmwr/volumes/70/wr/mm7036e2.htm


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Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021 | Infectious Diseases | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2784013?guestAccessKey=0c3ae017-8762-46e6-94df-cd1e03481fc6&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=090221

Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy | The BMJ

https://www.bmj.com/content/374/bmj.n1872

Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study - The Lancet Infectious Diseases

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00460-6/fulltext


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Continuity in general practice as a predictor of mortality, acute hospitalization, and use of out-of-hours services: registry-based observational study in Norway | British Journal of General Practice

https://bjgp.org/content/early/2021/08/26/BJGP.2021.0340


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Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMc2112981


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First findings from world’s largest study on long COVID in children | Science Media Centre

https://www.sciencemediacentre.org/first-findings-from-worlds-largest-study-on-long-covid-in-children/


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Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1537/5920279

mRNA vaccines for infectious diseases: principles, delivery and clinical translation | Nature Reviews Drug Discovery

https://www.nature.com/articles/s41573-021-00283-5


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Avances en gestión clínica: Transparencia y rendición de cuentas: diez puntos clave para un buen modelo

http://gestionclinicavarela.blogspot.com/2021/07/transparencia-y-rendicion-de-cuentas.html


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Outbreak Associated with SARS-CoV-2 B.1.617.2 (Delta) Variant in an Elementary School — Marin County, California, May–June 2021 | MMWR

https://www.cdc.gov/mmwr/volumes/70/wr/mm7035e2.htm


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Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2110475


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COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19: A Population-Based Cohort Study in Zhejiang Province, China | Global Health | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2783099?guestAccessKey=8d71c2a5-7acc-4049-aa73-e00a9a454a95&utm_source=twitter&utm_medium=social_jamaim&utm_term=5355731028&utm_campaign=article_alert&linkId=128706716


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mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

https://www.biorxiv.org/content/10.1101/2021.08.23.457229v1

Six-Month Effectiveness of BNT162B2 mRNA COVID-19 Vaccine in a Large US Integrated Health System: A Retrospective Cohort Study by Sara Y. Tartof, Jeff M. Slezak, Heidi Fischer, Vennis Hong, Bradley K. Ackerson, Omesh N. Ranasinghe, Timothy B. Frankland, Oluwaseye A. Ogun, Joann M. Zamparo, Sharon Gray, Srinivas R. Valluri, Kaijie Pan, Frederick J. Angulo, Luis Jodar, John M. McLaughlin :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3909743

Israel hopes boosters can avert new lockdown as Covid vaccine efficacy fades

https://www.ft.com/content/23cdbf8c-b5ef-4596-bb46-f510606ab556


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Use of Alternative Medicine for Cancer and Its Impact on Survival

https://academic.oup.com/jnci/article/110/1/121/4064136

SARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions | medRxiv

https://www.medrxiv.org/content/10.1101/2021.08.17.21262169v1

Transmission dynamics and epidemiological characteristics of Delta variant infections in China

https://www.medrxiv.org/content/10.1101/2021.08.12.21261991v1

Avances en gestión clínica: Las preguntas que interesan a los pacientes

Avances en gestión clínica: Las preguntas que interesan a los pacientes: Jordi Varela Editor En el universo de la actividad clínica ahora se conjugan, más que antes, los verbos educar, instruir y formar, informar ...

covid y vacunas.

Covid-19: How effective are vaccines against the delta variant?

https://www.bmj.com/content/374/bmj.n1960?utm_campaign=tbmj&utm_medium=cpc&utm_source=trendmd&utm_term=usage-042019&utm_content=consumer

Confronting the Delta Variant of SARS-CoV-2, Summer 2021

https://jamanetwork.com/journals/jama/fullarticle/2783478?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=081921#.YR34iQm9eMU.twitter

As Vaccines Wane, Immune System Still Has Weapons Against Delta

http://www.medscape.com/viewarticle/956662


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Differential Antibody Response to mRNA COVID-19 Vaccines in Healthy Subjects

https://journals.asm.org/doi/10.1128/Spectrum.00341-21

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study

 View ORCID ProfilePo Ying Chia,  View ORCID ProfileSean Wei Xiang Ong, Calvin J Chiew, Li Wei Ang, Jean-Marc Chavatte, Tze-Minn Mak, Lin Cui, Shirin Kalimuddin, Wan Ni Chia, Chee Wah Tan, Louis Yi Ann Chai, Seow Yen Tan, Shuwei Zheng, Raymond Tzer Pin Lin, Linfa Wang, Yee-Sin Leo, Vernon J Lee, David Chien Lye, Barnaby Edward Young

doi: https://doi.org/10.1101/2021.07.28.21261295

This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Conclusion The mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection. Vaccination is associated with faster decline in viral RNA load and a robust serological response. Vaccination remains a key strategy for control of COVID-19 pandemic.