domingo, 19 de febrero de 2017

Short term versus long term dual antiplatelet therapy after implantation of drug eluting stent in patients with or without diabetes: systematic review and meta-analysis of individual participant data from randomised trials

Doble antiagragacion en stents pauta larga o corta

Research

Short term versus long term dual antiplatelet therapy after implantation of drug eluting stent in patients with or without diabetes: systematic review and meta-analysis of individual participant data from randomised trials


Conclusions

Although the presence of diabetes emerged as an independent predictor of MACE, long term compared with short term DAPT did not reduce the risk of MACE but increased the risk of bleeding among patients with and without diabetes. This study might have relevant implications for clinicians and patients and could modify current daily clinical practice. A shorter DAPT regimen was found to be effective and safe in patients with and without diabetes. Diabetes per se should not be a driver for prolonging DAPT over the mandatory period after implantation of a drug eluting stent because of increased risks compared with potential benefits of this strategy. Future studies should be specifically designed and powered to deal with patients with diabetes and should explore the optimal duration of DAPT according to the type of diabetes and its medical management.

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