Este es un blog medico que nunca podrá sustituir el buen juicio médico en la toma de decisiones.Intentamos compartir con los profesionales nuestras experiencias, conocimientos,lecturas,etc con la finalidad de mejorar la practica clinica.No es un blog para pacientes aunque no rechazamos sus comentarios
domingo, 30 de enero de 2022
viernes, 28 de enero de 2022
lunes, 24 de enero de 2022
sábado, 22 de enero de 2022
jueves, 20 de enero de 2022
miércoles, 19 de enero de 2022
Impacto de la pandemia de COVID-19 en la seguridad del paciente percibida por los pacientes en Atención Primaria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708814/
Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination
SARS-CoV-2 Delta and Omicron strains are the most globally relevant variants of concern (VOCs). While individuals infected with Delta are at risk to develop severe lung disease, Omicron infection causes less severe disease, mostly upper respiratory symptoms. The question arises whether rampant spread of Omicron could lead to mass immunization, accelerating the end of the pandemic. Here we show that infection with Delta, but not Omicron, induces broad immunity in mice. While sera from Omicron-infected mice only neutralize Omicron, sera from Delta-infected mice are broadly effective against Delta and other VOCs, including Omicron. This is not observed with the WA1 ancestral strain, although both WA1 and Delta elicited a highly pro-inflammatory cytokine response and replicated to similar titers in the respiratory tracts and lungs of infected mice as well as in human airway organoids. Pulmonary viral replication, pro-inflammatory cytokine expression, and overall disease progression are markedly reduced with Omicron infection. Analysis of human sera from Omicron and Delta breakthrough cases reveals effective cross-variant neutralization induced by both viruses in vaccinated individuals. Together, our results indicate that Omicron infection enhances preexisting immunity elicited by vaccines, but on its own may not induce broad, cross-neutralizing humoral immunity in unvaccinated individuals.
https://www.medrxiv.org/content/10.1101/2022.01.13.22269243v1
martes, 18 de enero de 2022
domingo, 16 de enero de 2022
viernes, 14 de enero de 2022
WHO drugs covid
https://www.bmj.com/content/370/bmj.m3379
A living WHO guideline on drugs for covid-19
Actualización 13 de enero.
Por si es de utilidad.