PARTICIPA

PARTICIPA

lunes, 5 de diciembre de 2022

https://jamanetwork.com/journals/jama/fullarticle/2798745?guestAccessKey=99dd03e3-3730-4687-b04f-a8e27ee4da4e&utm_source=silverchair&utm_campaign=jama_network&utm_content=covid_weekly_highlights&utm_medium=email

https://jamanetwork.com/journals/jama/fullarticle/2798745?guestAccessKey=99dd03e3-3730-4687-b04f-a8e27ee4da4e&utm_source=silverchair&utm_campaign=jama_network&utm_content=covid_weekly_highlights&utm_medium=email


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Objetivos de presión arterial para el tratamiento de personas con hipertensión y enfermedad cardiovascular - Saiz, LC - 2022 | Cochrane Library

https://www.cochranelibrary.com/content?templateType=full&urlTitle=/cdsr/doi/10.1002/14651858.CD010315.pub5&doi=10.1002/14651858.CD010315.pub5&type=cdsr&contentLanguage=es


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Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes | Nature Medicine

https://www.nature.com/articles/s41591-022-02116-3


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Preparing for the "tripledemic": RSV, influenza, and COVID-19 | AAFP


Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis | BMC Medicine | Full Text


martes, 29 de noviembre de 2022

estatinas versus suplementos valoracion de NEJM

Statins vs. Supplements for Reducing Low-Density Lipoprotein Cholesterol

Fatima Rodriguez, MD, MPH, FACC, FAHA, reviewing 
In a randomized, controlled trial, a low dose of rosuvastatin wins by a landslide.
Patients commonly take supplements advertised to improve cardiovascular health, although the evidence to support this practice is limited. In the industry-funded Supplements, Placebo, or Rosuvastatin Study (SPORT) trial, investigators compared the efficacy for lowering low-density lipoprotein cholesterol (LDL-C) of six commonly used dietary supplements — fish oil, cinnamon, garlic, turmeric, plant sterols, and red yeast rice — with a low-dose statin and placebo.
One hundred and ninety-nine patients (mean age, 64 years; 59% women) with elevated LDL-C and increased 10-year risk of atherosclerotic cardiovascular disease identified from a single center were randomized to rosuvastatin (5 mg daily), placebo, or one of the supplements. The primary endpoint was the percent change of LDL-C from baseline after 28 days.
LDL-C percent reductions from baseline were significantly greater with rosuvastatin than with placebo (by an average difference of 35%) or any supplement. Compared with placebo, LDL-C was not significantly reduced with any of the supplements, and garlic was associated with a small but significant increase in LDL-C.

COMMENT

As a preventive cardiologist, I spend as much of my time in clinic convincing patients to take statins as I do telling them to throw away their untested dietary supplements. This highly practical study provides data to support this practice. Patients are better off skipping the supplements and sticking with statins.
Note: Karol E. Watson, MD is an author of this study and a co–Editor-in-Chief of NEJM Journal Watch Cardiology but had no role in selecting or summarizing this study.
At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.

CITATIONS

Laffin LJ et al. Comparative effects of low-dose rosuvastatin, placebo and dietary supplements on lipids and inflammatory biomarkers. J Am Coll Cardiol 2022 Oct 19; [e-pub]. (https://doi.org/10.1016/j.jacc.2022.10.013. opens in new tab)

Evaluación de la atención primaria, versión modificada del instrumento PCAT-A10 - ScienceDirect


¿Que dispositivo utilizo en broncodilatacion,? este articulo ayuda bastante. Desde Cadime.





 

Fwd: RECOMENDACIONES VACUNA PAPILOMA CONSEJO INTERTERRITORIAL



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Inicio del mensaje reenviado:


Asunto: RECOMENDACIONES VACUNA PAPILOMA CONSEJO INTERTERRITORIAL




Virus de papiloma humano

Las vacunas frente a VPH no contienen el virus completo ni material

 genético del virus, de forma que no pueden producir la enfermedad. La vacuna tiene la capacidad de estimular la producción de defensas (anticuerpos) frente a VPH.





miércoles, 23 de noviembre de 2022

Preevid: Utilidad del test de antígeno en heces en paciente con sospecha de infección por Helicobacter pylori. / Stool antigen test in patients with suspected Helicobacter pylori infection.

https://www.murciasalud.es/preevid/24931#


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Las sesiones de San Blas: Planes de Acción. Marcos estrategico Por Comunidades Autónomas

http://sesionessanblas.blogspot.com/2022/11/planes-de-accion-marcos-estrategico-por.html


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Overdiagnosis and overuse of diagnostic and screening tests in low-income and middle-income countries: a scoping review | BMJ Global Health

https://gh.bmj.com/content/7/10/e008696


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La consulta del doctor Casado: La solución de la Atención Primaria de Madrid. The solution for Primary Care in Madrid. 马德里初级保健解决方案。

https://doctorcasado.blogspot.com/2022/11/la-solucion-de-la-atencion-primaria-de.html


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sábado, 19 de noviembre de 2022

lunes, 14 de noviembre de 2022

Sano y salvo: Longitudinalidad en Atención Primaria: un factor protector de la salud. Editorial de la Revista Clínica de Medicina de Familia que mueve a la reflexión y a la acción

https://sano-y-salvo.blogspot.com/2022/06/longitudinalidad-en-atencion-primaria.html


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Preevid: ¿Que evidencias hay acerca de la efectividad de la oclusión de las úlceras corneales y su tratamiento medicamentoso?.


Should We Continue ACE Inhibitors and ARBs in Patients with Advanced Kidney Disease?

Should We Continue ACE Inhibitors and ARBs in Patients with Advanced Kidney Disease?

Allan S. Brett, MD, reviewing 
A randomized trial suggests that continuing them is safe in patients who are followed carefully.
Angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) can slow progression of mild-to-moderate chronic kidney disease (CKD). But are they beneficial, harmful, or neutral in patients with advanced CKD? To address this question, U.K. researchers identified 411 adults with estimated glomerular filtration rate (GFR) <30 mL/minute/1.73 m2 who had been receiving ACE inhibitors or ARBs and randomized them to discontinue or continue these drugs. At baseline, median serum creatinine was 3.4 mg/dL and median GFR was 18 mL/minute. Patients on dialysis were excluded.
At median follow-up of 3 years, these outcomes were noted:
  • Mean GFR was about 13 mL/minute in both groups; however, the proportion of patients progressing to renal replacement therapy or terminal palliative care was 62% with discontinuation and 56% with continuation; this difference just missed statistical significance (hazard ratio, 1.28; 95% confidence interval, 0.99–1.65).
  • Mortality was ≈10% in both groups.
  • Proteinuria and blood pressure increased transiently in the discontinuation group, but later, no differences were noted between groups.
  • Incidences of myocardial infarction, stroke, and heart failure hospitalizations were similar in the two groups.

COMMENT

Continuing ACE inhibitors or ARBs was not harmful in patients with estimated GFR lower than 30 mL/minute. The big question — not quite resolved here — is whether continuing these drugs confers any benefit: The 6 percentage-point difference in progression to end-stage renal disease, favoring the continuation group, would have been significant in a slightly larger study. In my view, these results support continuing ACE inhibitors and ARBs in patients with advanced CKD unless substantial hyperkalemia or otherwise unexplained sudden deterioration in renal function occurs.

Long-lasting Symptoms After an Acute COVID-19 Infection and Factors Associated With Their Resolution | Infectious Diseases | JAMA Network Open | JAMA Network

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798224


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sábado, 12 de noviembre de 2022

martes, 8 de noviembre de 2022

Frequency, signs and symptoms, and criteria adopted for long COVID‐19: A systematic review - PMC


Uso adecuado de los gabapentinoides – El rincón de Sísifo


Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study | The BMJ


El misterio de la demencia menguante: la proporción de personas mayores afectadas cae hasta un 30% en 15 años | Ciencia | EL PAÍS


Conciliación medicación crónicos

https://www.ismp-espana.org/ficheros/Conciliación%20en%20Atención%20Primaria-Pendiente%20NIPO-%20%20Octubre%202022.pdf

domingo, 6 de noviembre de 2022

Clinical Characteristics, Treatment Persistence, and Outcomes Among Patients With COPD Treated With Single- or Multiple-Inhaler Triple Therapy: A Retrospective Analysis in Spain - CHEST

https://journal.chestnet.org/article/S0012-3692(22)01212-0/fulltext


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IJERPH | Free Full-Text | Face-to-Face and Tele-Consults: A Study of the Effects on Diagnostic Activity and Patient Demand in Primary Healthcare

https://www.mdpi.com/1660-4601/19/21/14119


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Trial of an Intervention to Improve Acute Heart Failure Outcomes | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2211680


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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM

Parece que los fibratos en pacientes diabéticos con elevación de Triglicéridos y bajo Hdl colesterol no disminuye los eventos.
https://www.nejm.org/doi/full/10.1056/NEJMoa2210645


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martes, 1 de noviembre de 2022

Unintended consequences of patient online access to health records: a qualitative study in UK primary care | British Journal of General Practice


El Gerente De Mediado: Integralidad: la necesidad de un nuevo equipo

https://gerentedemediado.blogspot.com/2022/10/integralidad-la-necesidad-de-un-nuevo.html

National Imaging Trends for Suspected Urinary Stone Disease in the Emergency Department | JAMA Internal Medicine | JAMA Network

¿Con que prueba de imagen diagnosticamos litiasis colico nefritico en urgencias? Con RX? Eso es viejo oiga..

Curioso pero la asociacion de Urologia Americana recomienda como prueba de eleccion de imagen en urgencias el TAC frente a la ecografia(recomendada en asociaciones urologicas europeas).
En el estudio la cantidad de TAC frente a Eco es muy relevante y segun investigadores no se basa en ela superioridad en estudios(evidencia??)

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2798196?guestAccessKey=8a1c89e9-91be-4525-8b33-68d3486efb9c&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamainternalmedicine&utm_content=olf&utm_term=103122

Qualitative Analysis of Patient–Physician Discussions Regarding Anticoagulation for Atrial Fibrillation | JAMA Internal Medicine | JAMA Network

Medicina basada en valor. 
En el estudio se observa como los profesionales en la entrevista enfocan hacia el uso de anticoagulantes directo frente a Warfarina. Interesante como se detecta en las entrevistas grabadas.

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2798191?guestAccessKey=88e349ab-51fa-45c3-892b-f8cf8839b9ce&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamainternalmedicine&utm_content=olf&utm_term=103122

lunes, 24 de octubre de 2022

Right Bundle-Branch Block Pattern in Precordial Leads and Left Bundle-Branch Block Pattern With Left Axis Deviation in Frontal Plane Leads—What Does This Mean? | Cardiology | JAMA Internal Medicine | JAMA Network

para los frikis que les gustan los electrocardios dificiles

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2797847?guestAccessKey=e4c36e88-9c1f-4b25-8e96-01f5def61d38&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamainternalmedicine&utm_content=olf&utm_term=102422

Benefits of Streamlined Point-of-Care Trial Designs: Lessons Learned From the UK RECOVERY Study | Research, Methods, Statistics | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2797846?guestAccessKey=226daa45-5fa2-42fe-a3e9-a9a7b3b970d2&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamainternalmedicine&utm_content=olf&utm_term=102422

A ‘Tripledemic’? Flu and Other Infections Return as Covid Cases Rise - The New York Times


Risks and management for treating osteoporosis


domingo, 23 de octubre de 2022

Diarrea crónica: definición, clasificación y diagnóstico | Gastroenterología y Hepatología

https://www.elsevier.es/es-revista-gastroenterologia-hepatologia-14-articulo-diarrea-cronica-definicion-clasificacion-diagnostico-S0210570515002472

Avances en gestión clínica: ¿Cómo sacar el máximo provecho a la atención primaria virtual?

Esta frase citada abajo es mi impresion desde que me he incorporado a mi plaza basica como medico de atencion primaria:

"En primer lugar, los pacientes que tienen menor necesidad de atención sanitaria, los jóvenes y las personas de alto nivel socioeconómico, son los que tienen más posibilidades de beneficiarse del acceso virtual a la atención primaria".
"suelen ser patologias leves"
En el blog de gestion clinica Varela aportan informacion de esta posible alteracion de la digitalizacion.

jueves, 13 de octubre de 2022

Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion | NEJM


The data is clear: long Covid is devastating people’s lives and livelihoods | Tedros Adhanom Ghebreyesus | The Guardian


Post-acute symptoms four months after SARS-CoV-2 infection during the Omicron period: a nationwide Danish questionnaire study | medRxiv

https://www.medrxiv.org/content/10.1101/2022.10.12.22280990v1


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Translational gaps and opportunities for medical wearables in digital health | Science Translational Medicine

https://www.science.org/doi/10.1126/scitranslmed.abn6036


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Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2208681


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Colonoscopy Screening for Colorectal Cancer: A Randomized Trial


Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial - The Lancet

La pastilla de la tension por la mañana o por la tarde….Parece que da igual.

martes, 27 de septiembre de 2022

Long-term cardiac pathology in individuals with mild initial COVID-19 illness | Nature Medicine


Tweet de Eric Topol en Twitter



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Finding the equilibrium of empathy | The BMJ

https://www.bmj.com/content/378/bmj.o2288


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Managing peripheral oedema caused by calcium channel blockers – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice

https://www.sps.nhs.uk/articles/managing-peripheral-oedema-caused-by-calcium-channel-blockers/


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Más eficacia de inmunidad hibrida( vacuna infección)covid

https://www.cell.com/iscience/pdf/S2589-0042(22)01474-2.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004222014742%3Fshowall%3Dtrue

Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia | Nature Materials

https://www.nature.com/articles/s41563-022-01360-9


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martes, 13 de septiembre de 2022

Are Doctors Getting Their COVID Boosters? | MedPage Today

https://www.medpagetoday.com/special-reports/exclusives/100665


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How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) | European Heart Journal | Oxford Academic

https://academic.oup.com/eurheartj/article/40/40/3297/5557740


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Is 112 the New 10 000?—Step Count and Dementia Risk in the UK Biobank | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network

https://jamanetwork.com/journals/jamaneurology/fullarticle/2795818


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Effectiveness of a Fourth Dose of COVID-19 mRNA Vaccine Against Omicron Variant Among Elderly People in Singapore | Annals of Internal Medicine

https://www.acpjournals.org/doi/10.7326/M22-2042


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SARS-CoV-2 in immunocompromised individuals: Immunity

https://www.cell.com/immunity/fulltext/S1074-7613(22)00500-3


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viernes, 9 de septiembre de 2022

Understanding myalgic encephalomyelitis | Science

https://www.science.org/doi/10.1126/science.abo1261


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https://www.nature.com/articles/s41591-022-02000-0


En casos leves de Covid a los 100 días hasta 70%reportaban síntomas cardiológicos. Los siguieron con Rmn cardíaca…
https://www.nature.com/articles/s41591-022-02000-0


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Open-Source Automated Insulin Delivery in Type 1 Diabetes | NEJM

https://www.nejm.org/doi/full/10.1056/NEJMoa2203913


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Risk for Muscle Pain or Weakness with Statins Is Slight

https://www.jwatch.org/na55300/2022/09/06/risk-muscle-pain-or-weakness-with-statins-slight


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Growing Role of Gabapentin in Opioid-Related Overdoses Highlights Misuse Potential and Off-label Prescribing Practices | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2796287?guestAccessKey=b12b5e0b-0761-4db8-ba83-a78cac0c93bd&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=090722


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viernes, 2 de septiembre de 2022

Updates on COVID-19 Vaccine Effectiveness during Omicron

Actualizacion de la CDC de la efectividad de la vacuna. 


https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2022-09-01/04-COVID-Link-Gelles-508.pdf

Evasión de anticuerpos neutralizantes por sublinaje omicron BA.2.75

 Un sublinaje emergente, BA.2.75, está aumentando en frecuencia en India y se había detectado en al menos 15 países hasta el 19 de julio de 2022. Al parecer mantiene una menor frecuencia de escape que BA.5 y es aun sensible a algunos farmacos.

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00524-2/fulltext

How covid-19 spreads: narratives, counter narratives, and social dramas

Relato de como discusión entre transmision gotas versus aire genero consecuencias desfavorables en UK: 


https://www.bmj.com/content/378/bmj-2022-069940

jueves, 1 de septiembre de 2022

Frequency and estimated costs of ten low-value practices in the Spanish primary care: a retrospective study: Expert Opinion on Drug Safety: Vol 21, No 7

https://www.tandfonline.com/doi/full/10.1080/14740338.2022.2026924


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Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination | medRxiv


Preprint donde establece que el haber pasado la infección disminuye respuesta del booster por lo que hay que separarlo unos meses.

https://www.medrxiv.org/content/10.1101/2022.08.30.22279344v1


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JMIR Research Protocols - Using Artificial Intelligence as a Diagnostic Decision Support Tool in Skin Disease: Protocol for an Observational Prospective Cohort Study

https://www.researchprotocols.org/2022/8/e37531


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Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants | NEJM

En este articulo refuta el argumento de que infecciones previas de omicron no protegen de nuevas variantes de la misma.

We found that previous SARS-CoV-2 infection had a protective effect against BA.5 infection (Figure 1B and Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org), and this protection was maximal for previous infection with BA.1 or BA.2

https://www.nejm.org/doi/full/10.1056/NEJMc2209479


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