Pre-existing immunity to SARS-CoV-2: the knowns and unknowns | Nature Reviews Immunology

https://www.nature.com/articles/s41577-020-0389-z?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=NGMT_USG_JC01_GL_NRJournals

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Alessandro Sette &

07 July 2020

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating 'common cold' coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.