PARTICIPA

PARTICIPA

martes, 30 de abril de 2024

Deprescribing diabetes medications for older adults living with frailty | CMAJ


Distinguiendo nevus de melanoma plantar

He intentado contestar a una pregunta clinica con estos papers y se resuelve utilizando este esquema
muy recomendable esta pagina de dermatologo:
y en AMF medicos de familia:

Estrategias para la prevención y tratamiento no farmacológico de la diabetes. Modelos de atención - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0212656724000891

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Assessment and management of chronic insomnia disorder: an algorithm for primary care physicians | BMC Primary Care | Full Text

https://bmcprimcare.biomedcentral.com/articles/10.1186/s12875-024-02381-w

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martes, 23 de abril de 2024

Essential Guide To Safe Well Water Maintenance

If your home relies on well water, ensuring its safety and quality is your direct responsibility. Contaminated well water can harbor harmful bacteria, viruses, and chemicals that pose serious health risks. This comprehensive guide will arm you with the knowledge and best practices to maintain your well and ensure your family's drinking water is safe.

Why Well Water Maintenance Matters

  • Health Protection: Well water must be free from contaminants that can cause illness, particularly for vulnerable populations like infants, the elderly, or those with compromised immune systems.
  • Long-Term Well Functionality: Preventative maintenance prolongs the life of your well system, reducing costly repairs and replacements.
  • Peace of Mind: Staying on top of well inspection and management allows you to trust the water you drink and use.

Key Steps for Maintaining Your Well

1. Well Construction and Location

  • Professional Installation: Hire licensed well drillers to ensure proper construction, preventing surface water contamination.
  • Safe Site: The well should be situated away from potential contamination sources like livestock areas, septic systems, or chemical storage.
  • Uphill Placement: Wells installed on a slope should be uphill from contamination sources.

2. Regular Well Inspections

  • Annual Checkups: Schedule yearly inspections with a qualified well contractor to assess your system's overall condition.
  • Look for Changes: Monitor your well for any signs of damage, including cracks in the casing, a damaged or missing well cap, or pooling water near the wellhead.
  • Professional Assistance: If you detect any issues, contact a well professional immediately for repair.

3. Water Testing

  • Annual Testing (Minimum): Test your water for bacteria and nitrates at least once a year with a certified lab.
  • Contamination Suspicions: Immediately test your water if you notice changes in taste, odor, or color.
  • Nearby Activities: Test more frequently if activities near your well increase the risk of contamination (e.g., agriculture, new construction).

4. Maintaining the Wellhead

  • Secure and Sanitary Well Cap: Ensure your well cap is tightly sealed and free of cracks. It should have a vermin-proof screen over the vent.
  • Ground Slope: The ground around the well should slope away to prevent water pooling.
  • Keep it Clear: Maintain a clutter-free area around the well to limit pest habitats and simplify inspection.

5. Protecting Your Well from Contamination

  • Safe Distances: Keep known contamination sources (septic systems, livestock, fertilizer storage) well away from your well, following your local regulations for distances.
  • Mindful Chemical Use: Avoid using pesticides, herbicides, or fertilizers near the well.
  • Proper Waste Disposal: Never dispose of hazardous, chemical, or medical waste near your well.

Additional Tips

  • Well Records: Keep detailed records of well construction, testing results, and any repairs or maintenance.
  • Treatment Systems: If water tests indicate contamination, consider installing a suitable water treatment system.
  • Unused Wells: Decommission abandoned wells according to professional guidelines to protect groundwater.

The Importance of Professional Well Contractors

Always seek the expertise of licensed well contractors and pump installers for construction, repairs, and in-depth inspections. They possess the knowledge and tools to keep your well system operating effectively and safely.

By diligently following these guidelines, you'll significantly safeguard your family's health and ensure the longevity of your well water supply.

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Interstitial Lung Disease: A Review | Pulmonary Medicine | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2817849

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Semaglutide, Heart Failure, and Diabetes | New England Journal of Medicine

https://www.nejm.org/do/10.1056/NEJMdo007462/full/

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miércoles, 17 de abril de 2024

How To Get Rid of iron In Well Water

If you're struggling with rusty-looking stains on your sinks, a metallic taste in your water, or concerns about the safety of your well, the culprit is likely excess iron. Several proven methods exist to remove iron from your well water, including filtration, aeration, and oxidation. Understanding the causes of iron in your well and the various removal solutions empowers you to make the best decision for your home.

Iron naturally occurs in soil and rocks. As rainwater percolates through the ground, it can dissolve iron minerals, carrying them into your well water. This issue is particularly common in areas with naturally iron-rich geology or if you have older well components that may be corroding.

How Does Iron Get Into My Well Water?

The primary way iron enters well water is through natural processes. Groundwater seeps through iron-rich soil and rock formations, dissolving iron minerals along the way. Additionally, older well casings, pipes, or pumps made of iron-based materials can gradually rust, contributing to elevated iron levels in your well water.

What Problems Does Iron in Well Water Cause?

  • Staining: Iron in well water is notorious for leaving unsightly reddish-brown stains on your plumbing fixtures, sinks, tubs, laundry, and even dishes.
  • Metallic Taste and Odor: You may notice an unpleasant metallic taste or even a rusty odor in your drinking water and in beverages made with it.
  • Appliance Damage: Over time, iron buildup can clog pipes and reduce the lifespan of water heaters, dishwashers, and other appliances.
  • Potential Health Concerns: While iron is an essential nutrient, the EPA notes that excessive long-term consumption could pose health risks, primarily for individuals with certain medical conditions.
  • Iron Bacteria: Iron in well water can promote the growth of iron bacteria, leading to slimy buildups and a worsening of taste, odor, and clogging issues.

How Do I Test for Iron in My Well Water?

  • DIY Kits: Simple home test kits provide a basic indication of iron presence, but they may not be accurate enough for precise decision-making.
  • Professional Lab Testing: For comprehensive results and critical information about your exact iron levels and other water quality parameters, send a water sample to a certified lab. Local health departments or water treatment companies can often help you find testing services.

What Are the Best Ways to Remove Iron from Well Water?

  • Filtration Systems

    • Sediment Filters: These basic filters can remove some larger iron particles, but may be insufficient for higher iron levels.
    • Iron-Specific Filters: Specialized filters with various media types trap and remove iron effectively, making them a popular treatment solution.
    • Water Softeners: Traditional water softeners can remove small amounts of iron through ion exchange, but are more focused on addressing water hardness.
    • Maintenance: Regardless of the filter type, regular replacement according to the manufacturer's instructions and monitoring your water quality with testing will ensure continued effectiveness.
  • Aeration

    • Process: Aeration injects air into the water, oxidizing soluble ferrous iron into insoluble ferric iron, making it filterable.
    • Best for: Aeration is ideal for high iron levels and is often combined with filtration for optimal results.
  • Chemical Oxidation (Chlorination)

    • Process: Chlorine injection oxidizes iron and disinfects the water. Filtration then removes the oxidized particles.
    • Considerations: Chlorine can affect water taste, requiring additional filtration steps, and needs careful handling due to its potential hazards.
  • Other Methods

    • Reverse Osmosis: This removes a wide range of contaminants, including iron, but may be less cost-effective for targeting iron specifically.
    • Distillation: Similar to reverse osmosis, it's very effective but may not be practical as a primary solution for whole-house iron removal.

How Much Does Iron Removal Cost?

The cost to remove iron varies greatly depending on:

  • Iron Level: Higher iron concentrations may require more complex treatment systems.
  • Water Usage: The size of your household and water demand impact system capacity needs
  • Chosen Method: Simple filters are less expensive, while aeration or chlorination systems have higher upfront and potential maintenance costs.
  • DIY vs. Professional: Professional installation adds expense but is often recommended for complex setups.

Can I Remove Iron from My Well Water Myself?

The possibility of DIY installation depends on your skill level and the chosen method. Installing basic sediment filters or under-sink iron filters can be within a homeowner's capability. For whole-house systems, aeration, or chlorination, professional consultation and installation are usually the safest and most reliable route.

Resources:

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Impact of the timing of metformin administration on glycaemic and glucagon-like peptide-1 responses to intraduodenal glucose infusion in type 2 diabetes: a double-blind, randomised, placebo-controlled, crossover study | Diabetologia

https://link.springer.com/article/10.1007/s00125-024-06131-6

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lunes, 8 de abril de 2024

Well Water Safety: Testing, Contaminants, and Treatment Solutions

If you rely on a private well for your water supply, well water testing is essential to ensure the safety of your drinking water, as well as for overall household use. Unlike municipal water sources, which undergo regular treatment and monitoring, private wells are the homeowner's responsibility. This means that potential contaminants – whether from natural sources, human activities, or well system malfunctions – may not be detected without proactive testing.

Well water can harbor various contaminants that might affect your health. Bacteria, like E. coli, can cause gastrointestinal illnesses, while nitrates pose a particular risk for infants. Heavy metals like lead and arsenic have links to developmental problems and long-term health risks. Other contaminants, including minerals and chemicals, might not cause immediate illness but can affect the taste, odor, or appearance of your water.

Regular well water testing is the only way to proactively identify these potential issues. By understanding what's in your water, you can make informed decisions about treatment options and protect your household's health.

Why Well Water Testing Matters

Common Contaminants and Health Risks

It's crucial to understand that even clear, pleasant-tasting well water can contain harmful contaminants. Here are some of the most concerning categories:

  • Bacteria: Bacteria like coliform and E. coli can originate from septic systems or animal waste. They typically cause gastrointestinal issues like diarrhea, nausea, and vomiting.
  • Nitrates: Nitrates often leach into groundwater from fertilizers, septic systems, or livestock operations. They're particularly dangerous for infants, leading to "blue baby syndrome" (methemoglobinemia), a condition that reduces the blood's ability to carry oxygen.
  • Lead: Lead in drinking water often comes from corroded plumbing materials. Lead exposure can cause developmental delays and learning difficulties in children, and health problems in adults, including high blood pressure and kidney issues.
  • Arsenic: Arsenic is a naturally occurring element found in some rock formations. Long-term arsenic exposure increases the risk of various cancers, including skin, bladder, and lung cancer.
  • Radon: Radon is a radioactive gas that can seep into wells from underground sources. Exposure to radon is the second leading cause of lung cancer after smoking.
  • Other Contaminants: Well water can also contain excessive minerals (hardness, iron), pesticides, industrial chemicals, and other contaminants with varying health effects.

Long-Term Health Considerations

Some contaminants may not cause immediate illness, but their effects can accumulate with long-term exposure. Regular well water testing is the best way to monitor these potential risks and take action to keep your water safe. Additionally, well water testing gives you a baseline so you can detect any changes in your water quality over time.

Peace of Mind

Knowing what's in your well water offers peace of mind. When you're sure your water is safe, you can confidently use it for drinking, cooking, bathing, and other household activities, ensuring your family's health and well-being.

When to Test Your Well Water

Recommended Testing Frequency

The Centers for Disease Control and Prevention (CDC) recommends testing your well water at least annually for total coliform bacteria, nitrates, total dissolved solids, and pH levels. More frequent testing might be necessary depending on your area's risk factors or if you notice changes in your water.

Situations Requiring Immediate Testing

In addition to routine testing, schedule water testing immediately if you experience any of the following:

  • New Well or Major Repairs: If you have a newly constructed well or have undergone significant repairs, testing ensures it's producing safe water.
  • Changes in Water Quality: Changes in taste, odor, or appearance (cloudiness, unusual colors) can indicate contamination.
  • Gastrointestinal Illness: If household members experience unexplained stomach issues, test for bacterial contamination.
  • Infants or Pregnancy: Infants and pregnant women are more susceptible to waterborne contaminants, so extra precaution is vital.
  • Malfunctioning Septic Systems: Issues with your septic system increase the risk of groundwater contamination near your well.
  • Changes in Land Use: If new agricultural operations, industrial facilities, or other potential sources of contamination move near your property, prompt testing is warranted.

Staying Proactive

Remember, well water contamination isn't always obvious. Regular testing is a crucial part of responsible well ownership and ensures a safe drinking water supply for your household.

How to Get Your Well Water Tested

Types of Tests

  • DIY Test Kits: Home testing kits provide a basic analysis for some common contaminants like bacteria, nitrates, and pH. These kits offer limited accuracy and shouldn't replace thorough professional testing.
  • Professional Laboratories: Accredited laboratories offer comprehensive water testing services that analyze a wide range of contaminants, including bacteria, heavy metals, pesticides, and volatile organic compounds (VOCs). They provide detailed reports and guidance on interpreting results.

Finding Reputable Labs

Choosing a certified laboratory is critical for accurate results and reliable recommendations. Here's how to find one:

  • State Health or Environmental Departments: Contact your state health department or the equivalent environmental agency for a list of accredited water testing labs in your area.
  • Centers for Disease Control and Prevention (CDC): The CDC provides resources for finding certified laboratories.
  • Environmental Protection Agency (EPA): The EPA maintains a list of certified drinking water laboratories by state.

Understanding Your Test Results

Labs provide a detailed analysis of your water, including the levels of detected contaminants. Compare the results to the EPA's drinking water standards to determine if any contaminants exceed safe limits. Resources from agencies like the CDC and state health departments can help you interpret your results and determine the appropriate course of action.

What to Do If Your Well Water is Contaminated

Don't Panic

While concerning, most well water contamination issues are treatable. The first step is to understand the specific contaminants present, their potential health effects, and the appropriate remediation options.

Immediate Actions

  • Stop Drinking the Water: If contaminants exceed safe levels, immediately stop drinking and using your well water for cooking or brushing teeth.
  • Use Bottled Water: Use a reliable source of bottled water for drinking, cooking, and other essential needs until you implement a solution.

Seek Professional Guidance

  • Contact Your Health Department: Consult your state or local health department for guidance tailored to the specific contaminant(s) found in your water. They can help you understand health risks and recommend next steps.
  • Consult a Well Water Specialist: A certified well water contractor can assess your well system, identify potential contamination sources, and recommend treatment options.

Treatment Options

The best treatment solution depends on the type and level of contaminant(s). Some common options include:

  • Filtration Systems: Various filters target specific contaminants like bacteria, nitrates, heavy metals, or minerals.
  • Distillation: Distillation removes minerals, some metals, and effectively eliminates bacteria and viruses.
  • Chlorination: Chlorination effectively kills bacteria and viruses but may not address other contaminants.
  • Other Technologies: Technologies like reverse osmosis or ultraviolet (UV) light treatment offer solutions for a range of contaminants.

Choosing the Right Solution

Always consult with professionals to determine the most appropriate treatment system based on your test results, well characteristics, and household needs.

Well Maintenance for Safe Water

Alongside testing, regular well maintenance is crucial for protecting your water supply and extending the lifespan of your well system. Here's why it matters:

  • Preventing Contamination: Well maintenance helps identify and address potential points of contamination before they affect your water quality.
  • Ensuring System Functionality: Regular inspections catch mechanical issues early, preventing malfunctions that could compromise water safety or lead to costly repairs.
  • Proactive Protection: Well maintenance empowers you to take proactive steps safeguarding your drinking water, rather than just reacting to problems as they arise.

Key Maintenance Practices

  • Annual Inspections: Schedule yearly checkups with a qualified well contractor to inspect your well's casing, cap, and mechanical components.
  • Proper Location and Construction: Follow guidelines for well placement at a safe distance from potential contamination sources (septic systems, livestock pens, etc.). Ensure your well is constructed according to standards, with a sanitary seal preventing surface runoff from entering.
  • Protecting Your Wellhead: Maintain a clear area around your wellhead, keep it free of debris, and ensure the well cap is securely in place.
  • Monitoring for Changes: Be observant. Report any changes in your water, unusual activity around your well, or damage to the well.
  • Septic System Maintenance: Regularly pump and inspect your septic system to prevent malfunctions that could contaminate your well.

Safeguarding Your Well Water: Key Takeaways and Next Steps

Well water testing is an essential responsibility for private well owners. Regular testing identifies potential contaminants that may pose health risks, allowing you to make informed decisions about water treatment for safe consumption and household use. Understanding common contaminants, when to test, how to choose a lab, and simple maintenance practices significantly reduces risks and ensures ongoing access to safe drinking water.

Key Takeaways

  • Well water, unlike municipal water, isn't regularly treated or monitored.
  • Bacteria, nitrates, lead, arsenic, and other contaminants can jeopardize the safety of your water supply.
  • Test your well at least annually, and more often if risk factors are present or you notice changes in your water.
  • Professional water testing laboratories provide the most comprehensive analysis and guidance.
  • Prioritize regular well inspections and maintenance to prevent contamination and protect your investment.

Don't take chances with your family's health. If you rely on a private well:

  • Locate a certified water testing lab near you. Contact your state health department for resources as a starting point.
  • Schedule your initial well water test. Discuss the details of the testing process and expected timeframe for results with your chosen lab.
  • Consult a well water professional. Have a qualified contractor inspect your well system and offer advice on maintenance best practices.

By following these steps, you'll gain the peace of mind that comes from knowing your well water is safe and protecting the well-being of your household.

#wellwatertesting #wellwater #wellwatersafety #drinkingwater #groundwater #waterquality #homeowner #watercontamination #ruralliving #privatewell #health #bacteria #nitrates #arsenic #lead #homewater #watertreatment #cleanwater #watertest #watertestingkit

Resources:

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jueves, 4 de abril de 2024

plano ecocardiograficos

https://youtu.be/xdWbJFAGyKU?si=Jfy9ty4AKDIDaRsF

Fwd: MEDICINA CIENCIA Y ARTE



Viewpoint
April 3, 2024

Medicine—Both a Science (Care) and an Art (CARE)

JAMA. Published online April 3, 2024. doi:10.1001/jama.2024.2508

In the current era, health care is increasingly characterized by the integration of big data, predictive analytics, medical devices, and artificial intelligence. These technological advancements have undoubtedly transformed the landscape of medical care, offering unprecedented precision and efficiency in diagnosis and treatment.

Yet, amidst this surge of scientific innovation, the timeless art of medicine (compassion and caring) remains a foundational aspect of patient-centered health care.1 Despite the advances in technology, the qualities of compassion, assistance, active listening, respect, and empathy continue to be vital.2 These qualities not only contribute to better patient outcomes and increased satisfaction, but also play a crucial role in improving overall well-being.3

The acronym CARE (compassion, assistance, respect, and empathy) encapsulates these enduring values. These are not just words, but they are principles that guide the care of patients in a genuinely caring way. In a world increasingly driven by data and algorithms, these qualities foster a trusting and supportive relationship between health care professionals and patients, thereby enhancing the healing process and enriching the overall health care experience.

As described in their book,1 Trzeciak and Mazzarelli make it clear that compassion in health care transcends an emotional response; this is further nuanced by contemporary research. Empathy is the capacity to share and resonate with both the positive and negative feelings of others, which can lay the foundation for deep interpersonal connections. Compassion manifests as a feeling for others expressed through warmth, concern, and care, and is driven by a strong desire to enhance another individual's well-being.

Remarkably, compassion can be cultivated through training to build new skills with meditation and practice, thereby enhancing innate inclinations and adaptability to situational contexts. Trzeciak and Mazzarelli1 highlight that a genuine desire to assist is crucial, enabling the provision of care with the respect and dignity every patient deserves. This approach nurtures an empathetic understanding of a patient's situation. Consequently, CARE embodies both feelings and tangible actions.

As medicine and medical care have become more successful, and as science and technology improve diagnostic tools, therapeutics, and minimally invasive procedures, the personal interaction with patients and the belief that clinicians are compassionate has declined.3,4 Although robotics, artificial intelligence, electronic health records, telemedicine, and changing therapeutics are all important and have helped to improve the science of medicine, physicians can never forget that the art of medicine is just as important in patient healing.

Not unlike an artist who transforms beautiful colors only after the paint is skillfully and properly applied to the paint easel, this, too, must happen with the medical knowledge and skills physicians acquire. It is the responsibility of physicians to apply medical knowledge in their care of patients and provide individualized and unique medical CARE as its core. Health care must be integrated as both an art and a science. The "compassionomics" hypothesis of Trzeciak and Mazzarelli1 is: "There is science in the art of medicine."

All the scientific knowledge and skills acquired are rote unless applied to each patient with the art of care and compassion based on each patient's needs. "The compassion crisis will turn the profession of healthcare providers from a calling into a job."1 Compassion and caring are also greatly enhanced by one's spirituality. Studies have suggested that spirituality can have positive effects on patients' health care experiences.5,6 Research on spirituality6 indicates potential benefits such as improved coping mechanisms, reduced anxiety, and enhanced overall well-being.

Specific studies may focus on areas like mindfulness, prayer, or religious practices as components of spiritual care in health care settings. However, it is important to note that individual responses to spirituality can vary, and clinicians should approach this aspect of care with sensitivity and respect for diverse beliefs. Exploring needs and using spiritual aspects when caring for patients leads to a more empathetic and compassionate approach to the problem at hand no matter how large or small and no matter how routine or dire it may seem. It is about CARE.

As a profession, and as individual physicians, we cannot let computers and artificial intelligence purely dictate how we interact and care for our patients. Physicians need to be both scientists and artists applying the science with the artistic skills of CARE. This is our role in a world filled with facts without good interpretation, social media filled with misinformation, and the ability to access data with a simple click.

In an era when technology continuously redefines the boundaries of medical science, we stand at a pivotal crossroads. The question we face is not just about how advanced the tools and treatments can become, but about how deeply we can care for each individual who seeks healing. As we venture forward, each of us in the health care profession must ask ourselves: How will we blend the precision of science with the warmth of compassion in our daily practice? How can we ensure that our patients feel heard, respected, and genuinely cared for despite the inevitable march of medical innovation?

The challenge before us is to not only embrace the rapid advancements in medical science, but also to elevate the art of compassionate care. We must believe that caring and compassion make a difference. Compassionate care makes us all better healers. Caring is more than just medical treatment. It involves compassion, respect, kindness, and building trusting relationships. Compassionate care can improve patient outcomes, satisfaction, and loyalty as well as reduce stress and burnout for health care professionals.

Interventions that improve the patient-physician relationship are associated with better outcomes for patients and were recently assessed in a review by Malenfant et al.3 Compassion and caring must be taught and practiced alongside all learning from the very start of medical school through to the completion of the most specialized residencies to ensure the proper balance of CARE and caring (the science and the art).

As physicians have been moved away from direct patient contact because of technological advances, it is imperative that we understand how to use the best that science and technology now offer. We must do so in ways that reconnect us with patients personally and the CARE that is at the core of those relationships. "No one cares how much you know, until they know how much you care" (speaker unknown but often attributed to Theodore Roosevelt).

Back to top
Article Information

Corresponding Author: Theodore J. Strange, MD, Northwell Health System, 2000 Marcus Ave, New Hyde Park, NY 11042 (tstrange@northwell.edu).

Published Online: April 3, 2024. doi:10.1001/jama.2024.2508

Conflict of Interest Disclosures: None reported.

References
1.
Trzeciak  S, Mazzarelli  A.  Compassionomics: The Revolutionary Scientific Evidence That Caring Makes a Difference. Huron Consulting Services LLC; 2019.
2.
American Medical Association. AMA principles of medical ethics. Accessed January 18, 2024. https://code-medical-ethics.ama-assn.org/principles
3.
Malenfant  S, Jaggi  P, Hayden  KA, Sinclair  S.  Compassion in healthcare: an updated scoping review of the literature.   BMC Palliat Care. 2022;21(1):80. doi:10.1186/s12904-022-00942-3PubMedGoogle ScholarCrossref
4.
Hryciw  BN, Fortin  Z, Ghossein  J, Kyeremanteng  K.  Doctor-patient interactions in the age of AI: navigating innovation and expertise.   Front Med (Lausanne). 2023;10:1241508. doi:10.3389/fmed.2023.1241508Google ScholarCrossref
5.
Balboni  TA, VanderWeele  TJ, Doan-Soares  SD,  et al.  Spirituality in serious illness and health.   JAMA. 2022;328(2):184-197. doi:10.1001/jama.2022.11086
ArticlePubMedGoogle ScholarCrossref
6.
VanderWeele  TJ, Balboni  TA, Koh  HK.  Health and spirituality.   JAMA. 2017;318(6):519-520. doi:10.1001/jama.2017.8136
ArticlePubMedGoogle ScholarCrossref


martes, 2 de abril de 2024

Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis - The Lancet Rheumatology

VASCULITIS 

The artificial intelligence revolution in primary care: Challenges, dilemmas and opportunities - ScienceDirect


Health Care AI and Patient Privacy—Dinerstein v Google | Law and Medicine | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2815451

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Atherosclerotic coronary plaque regression from lipid-lowering therapies: A meta-analysis and meta-regression - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S2666667724000138

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How Treatment Effect Heterogeneity Works | NEJM Evidence - YouTube

https://www.youtube.com/watch?v=oqXLqc4oxUM

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